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Blastomycosis: Report of three cases from Alberta with a review of Canadian cases

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Abstract

Approximately 120 cases of blastomycosis have been reported from Canada to-date. The great majority of these occurred in the Eastern provinces. Since 1970, three cases of blastomycosis have been seen in Alberta. The first case, with meningeal and pulmonary involvements, was diagnosed at post-mortem. The second case was that of a 75-year-old male with a history of pancytopenia, aortic arteriosclerosis, exposure to mercury, and fever. KOH and periodic-acid schiff (PAS) stained smears of the lung tissue, received after autopsy, showed numerous budding yeast cells of Blastomyces dermatitidis along with some hyphal filaments. Similarly, budding cells of B. dermatitidis and hyphal segments were observed in large numbers in the PAS and Gomori's methenamine-silver (GMS) stained sections made from adrenals, lung, kidney, and spleen tissues. Attempts to culture the fungus on a variety of selective and non-selective media were unsuccessful, due to heavy bacterial contamination. The indirect fluoroscent antibody results were 2+ with the B. dermatitidis conjugate. The third case was that of a 31-year-old male, who was admitted to the hospital with the chief complaint of chest pain. Biopsy tissue sections, stained with the GMS procedure revealed a few foci with B. dermatitidis yeast cells. The immunodiffusion and complement fixation (CF) tests gave positive results against B. dermatitidis antigen (titre, 1∶16). The CF titre declined following treatment with amphotericin B and the immunodiffusion test became negative after the institution of antifungal therapy. Except for the last patient, the other two patients had no history of travel in any known endemic areas. In addition to these cases, a survey of blastomycosis occurring in this country has been presented along with on the disease in dogs and a cat.

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References

  1. Ajello, L. 1969. A comparative study of the pulmonary mycoses of Canada and the United States. Public Health Reports 84: 869–877.

    Google Scholar 

  2. Ajello, L. 1975. The medical mycological iceberg. In: Al-Doory, Y. (ed.), The Epidemiology of Human Mycotic Diseases. Charles C. Thomas. Springfield, Illinois, pp. 209–306.

    Google Scholar 

  3. Aszkanazy, C.L., H.J. Barrie & J. H. Crookston. 1951. Systemic blastomycosis. Can. J. Med. Assoc. 65: 55–66.

    Google Scholar 

  4. Badame, F.G. & G.K. Peck. 1960. Blastomycosis in a dog. Can. Vet. J. 1: 177–179.

    Google Scholar 

  5. Chick, E.W. 1975. The epidemiology of blastomycosis. In: Al-Dorry, Y. (ed.), The Epidemiology of Human Mycotic Diseases. Charles C. Thomas. Springfield, Illinois, pp. 103–116.

    Google Scholar 

  6. Dion, W.M. & L. Kapica. 1975. Isolation of dermatophytes, Candida species and systemic fungi from dermatological specimens in Montreal, 1963–1973. Can. Med. Assoc. J. 112: 712–716.

    Google Scholar 

  7. Ditchfield, J. & J.B. Fisher. 1961. North American blastomycosis in the dog; with a report of six Canadian cases. Can. Vet. J. 2: 103–111.

    Google Scholar 

  8. Dorray, M., R. Guy, P. Dionne, B.-G., Begin & J. Lambert. 1957. Un cas de blastomycose nord-americaine traitee avec succes par la 2-hydroxy-stilbamidine. Un. med. Can. 86: 182–187.

    Google Scholar 

  9. Drummond, K.L. & J.D. Smith. 1950. Systemic blastomycosis. Can. Med. Assoc. J. 63: 598–599.

    Google Scholar 

  10. Easton, K.L. 1961. Cutaneous North American blastomycosis in a siamese cat. Can. Vet. J. 2: 350–351.

    Google Scholar 

  11. Elliot, G.B., J.C. Wilt & M. Duggan. 1952. Cutaneous and systemic North American blastomycosis. Can. Med. Assoc. J. 67: 650–653.

    Google Scholar 

  12. Emmons, C.W., C.H. Binford, J.P. Utz & K. J. Kwon-Chung. 1977. Medical Mycology, p. 592, Third Edition, Lea & Febiger, Philadelphia, U.S.A.

    Google Scholar 

  13. Forsey, R.R. & R. Jackson. 1953. Toxic psychosis following use of stilbamidine in blastomycosis. Arch. Dermatol. Syph. 68: 89–90.

    Google Scholar 

  14. Gaumond, E. 1953. Onze cas de blastomycose nordamericaine daus la region de Quebec. Laval Med. 18: 1319–1344.

    Google Scholar 

  15. Getzler, N.A. & R.D. Wilkinson. 1970. Cutaneous North American blastomycosis: report of a case from central Canada. Can. Med. Assoc. J. 103: 174–176.

    Google Scholar 

  16. Giroux, M. & R. Dessureault. 1955. Blastomycose generalisee. Laval Med. 20: 1326–1332.

    Google Scholar 

  17. Gordon, C.A. & W.B. Stewart. 1960. Treatment of North American blastomycosis with amphotericin B. Can. Med. Assoc. J. 82: 471–473.

    Google Scholar 

  18. Graham, J.E.B. & R.J. Ketchell. 1958. North American blastomycosis: a Canadian case report. Can. J. Comp. Med. 22: 125–126.

    Google Scholar 

  19. Grandbois, J. 1958. The modern treatment of North American blastomycosis. Can. Med. Assoc. J. 79: 828–832.

    Google Scholar 

  20. Grandbois, J. 1963. La blastomycose nord-americaine an Canada. (Releve de tous les cas publies et non publies et resultats obtenus chez quatreo patients traites par l'amphotericine B). Laval Med. 34: 714–731.

    Google Scholar 

  21. Grandbois, J., M. Giroux, J. Gravel & M. Beaulieu. 1957. Le 2-hydrostilbamidine dans le traitment de la blastomycose nord-americaine. Laval Med. 24: 165–183.

    Google Scholar 

  22. Grice, H.C., T. Balazs, J.A. Hutchinson & J. Ditchfield. 1961. North American blastomycosis — a report of 2 cases in dogs. Can. Vet. J. 2: 221–225.

    Google Scholar 

  23. Hardin, H.F. & D.I. Scott. 1974. Blastomycosis: Occurrence of filamentous forms in vivo. Am. J. Clin. Pathol. 62: 104–106.

    Google Scholar 

  24. Jacobs, H.J. et al. 197.. Blastomycosis: A case report from Alberta (under preparation).

  25. Kaufman, L. 1976. Serodiagnosis of fungal diseases, p. 363–381, In Manual of Clinical Immunology, (ed.) N.R. Rose & H. Friedman. American Soc. Microbiol., Washington, D.C.

    Google Scholar 

  26. Kepron, M.W., C.B. Schoemperlen, E.S. Hershfield, C.J. Zylak & R.M. Cherniack. 1972. North American blastomycosis in central Canada. A review of 36 cases. Can. Med. Assoc. J. 106: 243–246.

    Google Scholar 

  27. Lamoureux, M. & G. Leclerc. 1948. Blastomycose. Un. med. Can. 77: 1002–1003.

    Google Scholar 

  28. Leduc, A. 1953. Mycose pulmonaires. Un. med. Can. 82: 790–793.

    Google Scholar 

  29. Leduc, A. 1953. Blastomycose de l'Amerique du nord (maladie de Gilchrist). Considerations mycologiques. Un. med. Can. 82: 790–793.

    Google Scholar 

  30. Leers, W.-D., N.A. Russell, & G. Laroye. 1972. Cerebellar abscess due to Blastomyces dermatitidis. Can. Med. Assoc. J. 107: 657–660.

    Google Scholar 

  31. McKee, S.H. 1930. Blastomycosis of the eye. Can. Med. Assoc. J. 22: 501–503.

    Google Scholar 

  32. McLaren, J.A. 1949. North American blastomycosis. Can. Med. Assoc. J. 60: 26–32.

    Google Scholar 

  33. Morbidity and Mortality Weekly Report, Vol. 25, No. 53-Annual Summary (1976). Department of Health, Education and Welfare, Centre for Disease Control, Atlanta, Georgia 30333, U.S.A.

  34. Opie, L.H., I.A.d. Todd & E.A. Allen. 1963. Genitourinary blastomycosis. Can. Med. Assoc. J. 89: 79–82.

    Google Scholar 

  35. Poirier, P. 1955. Blastomycose nord-americaine (maladie de Gilchrist). Un. med. Can. 84: 247.

    Google Scholar 

  36. Rippon, J.W. 1974. Medical Mycology, The Pathogenic Fungi and Pathogenic Actinomycetes, p. 587, W.B. Saunders Company, Philadelphia, London, Toronto.

    Google Scholar 

  37. Robinson, Jr., H.M. 1974. The diagnosis and treatment of fungal infections, p. 560, Charles C. Thomas, Springfield, Illinois.

    Google Scholar 

  38. Savage, A., B.R. Boycott & L.J. Villa. 1962. North American blastomycosis in a dog. Can. Vet. J. 3: 260–262.

    Google Scholar 

  39. Sekhon, A.S. & J.W. Carmichael. 1972. Pyrolysis-gas-liquid chromatography of some dermatophytes. Can. J. Microbiol. 18: 1593–1601.

    Google Scholar 

  40. Soltys, M.A. & G. Sumner-Smith. 1971. Systemic mycoses in dogs and cats. Can. Vet. J. 12: 191–199.

    Google Scholar 

  41. Starrs, R.A. & M.O. Klotz. 1948. North American blastomycosis (Gilchrist's disease). II. An analysis of Canadian reports and description of a new case of the systemic type. Arch. Inter. Med. 82: 29–53.

    Google Scholar 

  42. Watson, S.H., S. Moore & F. Blank. 1958. Generalized North American blastomycosis. Can. Med. Assoc. J. 78: 35–38.

    Google Scholar 

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Authors and Affiliations

  1. Provincial Laboratory of Public Health, The University of Alberta, T6G 2J2, Edmonton, Alberta, Canada

    Awatar S. Sekhon

  2. Calgary Medical Laboratories, Box 2626, T2P 2M7, Calgary, Alberta, Canada

    M. S. Bogorus

  3. Department of Laboratory Medicine, Calgary General Hospital, T2E 0A1, Calgary, Alberta, Canada

    H. V. Sims

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  1. Awatar S. Sekhon
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  2. M. S. Bogorus
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  3. H. V. Sims
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Sekhon, A.S., Bogorus, M.S. & Sims, H.V. Blastomycosis: Report of three cases from Alberta with a review of Canadian cases. Mycopathologia 68, 53–63 (1979). https://doi.org/10.1007/BF00490391

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