Regular ArticlePrediction of Recurrent and Residual Cervical Dysplasia by Human Papillomavirus Detection among Patients with Abnormal Cytology
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Cited by (79)
Study of high-risk hpv infection clearance after conization
2021, Clinica e Investigacion en Ginecologia y ObstetriciaValue of endocervical margin and high-risk human papillomavirus status after conization for high-grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and microinvasive carcinoma of the uterine cervix
2014, Gynecologic OncologyCitation Excerpt :Colposcopy with directed biopsy has been shown to miss residual/recurrent lesions [3]. In addition, the Papanicolaou (Pap) test has some inherent flaws due to its relatively high rate of false negativity and low sensitivity after the conization [4,5]. Therefore, annual cervical cytology accompanied by human papillomavirus (HPV) testing at 12 and 24 months has been recently used to monitor for women treated for high-grade CIN because high-risk (HR)-HPV assessment is beneficial in identifying the undetected high-grade residual/recurrent disease [6].
Assessment of HPV-mRNA test to predict recurrent disease in patients previously treated for CIN 2/3
2014, Journal of Clinical VirologyFollow-up after LLETZ: A study of 682 cases of CIN 2-CIN 3 in a single institution
2012, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :In our study, we found no significant difference with respect to age between patients with normal follow-up and those who had a recurrent or persistent lesion. Numerous studies have shown that there is a highly significant association between persistent infection with HR-HPV and persistent or recurrent disease [13,18,22]. In our work, the HPV testing was made initially with PCR but since 2003, our laboratory has used the HC II test routinely.
Predictors of recurrence in high-grade cervical lesions and a plan of management
2010, European Journal of Surgical OncologyCitation Excerpt :An indicator that predicts successful outcome thus allowing to minimize the follow-up period would be particularly helpful. Several authors suggest follow-up after treatment should combine the HR-HPV test with the smear as it identifies patients with high risk of recurrence.4,12,29 We suggest HPV test after treatment would be useful when surgical margins are positive because even if the PNV is not much improved (respectively 90.8% and 97%), PPV is improved by 70% (respectively 31.2% and 100%).
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To whom correspondence and reprint requests should be addressed at the Department of Virology, Academic Medical Center, Building L1, Room 158, Meibergdreef 15, 1105 A2 Amsterdam, The Netherlands. Fax: 31206979271.