Association between statin dose and 1-year mortality in older Ontario residents living in long-term care facilities who were prescribed statins, overall and by subgroup*
| Analysis | No. of matched pairs analyzed | One-year survival in residents taking intensive-dose statins, % | One-year survival in residents taking moderate-dose statins, % | Risk difference in 1-year survival, % (95% CI) | HR† (95% CI) |
|---|---|---|---|---|---|
| Primary analysis, all matched pairs | 4577 | 74.37 | 73.56 | 0.81 (−0.99 to 2.61) | 0.97 (0.90 to 1.05) |
| Stratified analysis | |||||
| Sex | |||||
| Female | 2776 | 77.70 | 76.08 | 1.62 (−0.60 to 3.84) | 0.93 (0.83 to 1.03) |
| Male | 1801 | 69.24 | 69.68 | −0.44 (−3.45 to 2.57) | 1.02 (0.91 to 1.15) |
| History of atherosclerotic-related admission to hospital | |||||
| No | 1560 | 78.72 | 76.67 | 2.05 (−0.88 to 4.97) | 0.91 (0.79 to 1.05) |
| Yes | 3017 | 72.12 | 71.96 | 0.16 (−2.11 to 2.43) | 1.00 (0.91 to 1.09) |
| Frailty status | |||||
| Prefrail or not frail | 2119 | 82.77 | 83.48 | −0.71 (−2.97 to 1.55) | 1.05 (0.91 to 1.21) |
| Frail | 2458 | 67.13 | 65.01 | 2.12 (−0.53 to 4.77) | 0.93 (0.85 to 1.03) |