Hazard ratios for covariates in multivariable-adjusted Cox regression models for all dementia and all cerebrovascular disease
| Covariate | HR (95% CI) | |
|---|---|---|
| All dementia | All cerebrovascular disease | |
| APOE genotype | ɛ22: 0.60 (0.29–1.27) | ɛ22: 0.89 (0.66–1.21) |
| ɛ32: 0.80 (0.69–0.94) | ɛ32: 1.00 (0.93–1.08) | |
| ɛ33: 1.00 (Ref.) | ɛ33: 1.00 (Ref.) | |
| ɛ42: 1.34 (1.04–1.74) | ɛ43: 1.01 (0.95–1.06) | |
| ɛ43: 2.03 (1.85–2.23) | ɛ42: 1.17 (1.03–1.34) | |
| ɛ44: 5.77 (4.89–6.81) | ɛ44: 1.30 (1.15–1.48) | |
| Male sex | 0.62 (0.40–0.96) | 0.64 (0.57–0.73) |
| Body mass index | ||
| Lowest tertile (CCHS: < 23.3; CGPS: < 24.0) | 1.00 (Ref.) | 1.00 (Ref.) |
| Middle tertile (CCHS: 23.3–26.8; CGPS: 24.0–27.4) | 0.97 (0.88–1.08) | 0.98 (0.93–1.04) |
| Highest tertile (CCHS: > 26.8; CGPS: > 27.4) | 0.96 (0.86–1.07) | 1.04 (0.98–1.10) |
| Hypertension* | 0.82 (0.74–0.91) | 1.17 (1.11–1.24) |
| Diabetes mellitus† | 1.30 (1.09–1.55) | 1.02 (0.93–1.11) |
| Smoking‡ | 1.68 (1.52–1.85) | 1.49 (1.41–1.57) |
| Alcohol consumption§ | 1.00 (0.89–1.12) | 0.97 (0.92–1.03) |
| Physical inactivity¶ | 1.16 (1.06–1.27) | 1.13 (1.08–1.18) |
| Postmenopausal status and hormonal replacement therapy** | ||
| Premenopausal | 1.00 (Ref.) | 1.00 (Ref.) |
| Postmenopausal without hormonal replacement therapy | 0.65 (0.42–1.00) | 0.47 (0.42–0.54) |
| Postmenopausal with hormonal replacement therapy | 0.72 (0.46–1.13) | 0.53 (0.46–0.62) |
| Lipid-lowering therapy†† | 0.81 (0.71–0.93) | 2.25 (2.13–2.38) |
| Education < 8 yr | 1.34 (1.23–1.47) | 1.02 (0.97–1.07) |
| Atrial fibrillation‡‡ | – | 1.52 (1.44–1.61) |
Note: CCHS = Copenhagen City Heart Study, CGPS = Copenhagen General Population Study, CI = confidence interval, Ref. = reference.
↵* Hypertension was defined by use of antihypertensive medication, systolic blood pressure of ≥ 140 mm Hg, and/or diastolic blood pressure of ≥ 90 mm Hg.
↵† Diabetes mellitus was defined by self-reported disease, use of insulin or oral hypoglycemic agents, and/or nonfasting plasma glucose level of > 11 mmol/L (> 198 mg/dL).
↵‡ Smoking was defined by current smoking.
↵§ Alcohol consumption was defined by > 14/21 units per week for women/men (1 unit = 12 g alcohol, equivalent to 1 glass of wine or spirit or 1 beer [33 cL = 330 mL]).
↵¶ Physical inactivity was defined by ≤ 4 hours per week of light physical activity in leisure time.
↵** Women reported menopausal status and use of hormonal replacement therapy. The individual hazard ratios for postmenopausal status and hormonal replacement therapy should be interpreted with caution, because the covariate in itself reflects age, and these estimates are from the full model with adjustment for age as the time scale. Adjusting for postmenopausal status and hormonal replacement therapy as a covariate is still appropriate, and the inclusion of this does not change the genetic estimates (Appendix 1, Supplemental Table 1).
↵†† Lipid-lowering therapy primarily consisted of statins (yes/no).
↵‡‡ Atrial fibrillation was defined by any diagnosis of atrial fibrillation ever.