Table 1:

Characteristics of 104 537 study participants by APOE genotype^*

Characteristic	% of participants^†
Characteristic	ɛ22	ɛ32	ɛ33	ɛ42	ɛ43	ɛ44
Individuals, no. (%)	715 (0.7)	12 994 (12.4)	58 172 (55.6)	3013 (2.9)	26 626 (25.5)	3017 (2.9)
Age, yr, mean ± SEM	57.3 ± 0.5	58.0 ± 0.1	57.9 ± 0.1	57.4 ± 0.2	57.5 ± 0.1	56.6 ± 0.2
Female sex	55	55	55	55	55	57
Body mass index, mean ± SEM	26.2 ± 0.2	26.2 ± 0.0	26.1 ± 0.0	26.1 ± 0.1	26.0 ± 0.0	25.9 ± 0.1
Hypertension^‡	58	59	60	59	59	58
Diabetes mellitus^§	3	4	4	4	4	4
Smoking^¶^**	19	21	21	20	21	19
Alcohol consumption^**^††	17	18	17	16	17	16
Physical inactivity^**^‡‡	50	51	51	49	50	49
Postmenopausal^**^§§	62	67	68	65	67	65
Hormone replacement therapy^**^§§	11	11	11	11	11	11
Lipid-lowering therapy^**^¶¶	7	7	11	9	13	15
Education < 8 yr	11	13	13	12	12	11
Atrial fibrillation^***	7	7	7	7	7	7

Note: SEM = standard error of the mean.
↵* Values are from the day of enrolment (2003–2014 for the Copenhagen General Population Study and 1991–1994 or 2001–2003 for the Copenhagen City Heart Study). Missing data on categorical and continuous covariates (< 0.4%) were imputed from age, sex and population using multiple imputations.
↵† Unless stated otherwise.
↵‡ Hypertension was defined by the use of antihypertensive medication, systolic blood pressure of ≥ 140 mm Hg, and/or diastolic blood pressure of ≥ 90 mm Hg.
↵§ Diabetes mellitus was defined by self-reported disease, use of insulin or oral hypoglycemic agents, and/or nonfasting plasma glucose level of > 11 mmol/L (> 198 mg/dL).
↵¶ Smoking was defined by current smoking.
↵** Smoking, alcohol consumption, physical inactivity, menopausal status, hormonal replacement therapy, lipid-lowering therapy, and education were self-reported and reviewed together with an investigator on the day of attendance to clarify any uncertainties.
↵†† Alcohol consumption was defined by > 14/21 units per week for women/men (1 unit = 12 g alcohol, equivalent to 1 glass of wine or spirit or 1 beer [33 cL = 330 mL]).
↵‡‡ Physical inactivity was defined by ≤ 4 hours per week of light physical activity in leisure time.
↵§§ In women only (n = 57 543). Women reported menopausal status and use of hormonal replacement therapy.
↵¶¶ Lipid-lowering therapy primarily consisted of statins (yes/no).
↵*** Atrial fibrillation was defined by any diagnosis of atrial fibrillation ever.