Absolute and relative rate of fragility fracture among cases compared with controls*
| Characteristic | Unexposed | Exposed | Unadjusted HR (95% CI) | Adjusted HR‡ (95% CI) | ||
|---|---|---|---|---|---|---|
| n | Rate† (95% CI) | n | Rate‡ (95% CI) | |||
| Overall | 7164 | 54.7 (53.5–56.0) | 1770 | 52.9 (50.5–55.6) | 0.97 (0.92–1.02) | 0.95 (0.89–1.01) |
| Age, yr (quartile) | ||||||
| 1 | 683 | 18.3 (16.9–19.7) | 179 | 18.6 (16.1–21.6) | 1.02 (0.86–1.20) | 0.90 (0.73–1.10) |
| 2 | 1147 | 32.2 (30.3–34.0) | 296 | 32.7 (29.2–36.7) | 1.01 (0.90–1.16) | 0.92 (0.79–1.07) |
| 3 | 2020 | 61.7 (59.1–64.5) | 505 | 61.7 (56.6–67.4) | 1.02 (0.92–1.12) | 1.01 (0.91–1.14) |
| 4 | 3314 | 132.4 (127.9–136.9) | 790 | 119.6 (111.6–128.3) | 0.92 (0.85–1.00) | 0.94 (0.86–1.03) |
| Sex | ||||||
| Male | 3016 | 30.9 (29.4–32.0) | 793 | 31.5 (29.4–33.8) | 1.02 (0.94–1.10) | 0.99 (0.90–1.09) |
| Female | 4148 | 124.7 (121.0–128.5) | 977 | 117.7 (110.5–125.3) | 0.96 (0.89–1.02) | 0.94 (0.87–1.01) |
Note: BMI = body mass index, CI = confidence interval, HR = hazard ratio.
↵* Multiple imputation was used to replace missing values of BMI using a chain equation approach based on all baseline characteristics. Five imputed data sets were created and results were combined across all data sets using the Rubin rule to obtain final estimates.
↵† Per 10 000 person-years.
↵‡ Adjusted for age, alcohol consumption, smoking status, BMI, Charlson index, opioids, fall, glucocorticoids, nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, proton pump inhibitors, antidiabetic and antihypertensive agents, and selective serotonin reuptake inhibitors.