Table 2:

Relative risk of ischemic stroke among patients with and without concomitant exposure to other antihypertensive agents at index date of α-blocker therapy

Period^*	Concomitant use of antihypertensive agents		No concomitant use of antihypertensive agents

	Unadjusted IRR (95% CI)	Adjusted IRR^† (95% CI)	Unadjusted IRR (95% CI)	Adjusted IRR^† (95% CI)
Unexposed (ref)	1.00	1.00	1.00	1.00

Pre-exposure

Risk period 2 (−22 to −60 d)	2.01 (1.80–2.24)	2.05 (1.84–2.28)	1.85 (1.57–2.17)	1.89 (1.61–2.22)

Risk period 1 (−1 to −21 d)	2.91 (2.58–3.28)	2.94 (2.61–3.32)	2.66 (2.22–3.18)	2.71 (2.27–3.24)

Post-exposure

Risk period 1 (≤ 21 d)	1.09 (0.90–1.32)	1.07 (0.88–1.29)	2.10 (1.72–2.56)	2.11 (1.73–2.57)

Risk period 2 (22 to 60 d)	0.69 (0.58–0.83)	0.67 (0.56–0.81)	1.07 (0.87–1.31)	1.06 (0.86–1.31)

Note: CI = confidence interval, IRR = incidence rate ratio, ref = reference category.
↵* See the Methods and Figure 1 for details about the periods.
↵† Adjusted for age and development of atrial flutter/fibrillation.