Characteristics of randomized controlled trials included in the meta-analysis
| Study | No. of patients | Surgical procedure | Lung-protective ventilation | Conventional ventilation | Outcomes | ||||
|---|---|---|---|---|---|---|---|---|---|
| Tidal volume, mL/kg | PEEP, cm H2O | Recruitment manoeuvre | Tidal volume, mL/kg | PEEP, cm H2O | Recruitment manoeuvre | ||||
| Chaney et al., 200020 | 25 | CABG | 6 | 5 | No | 12 | 5 | No | Mortality, length of hospital stay, Paco2 level |
| Koner et al., 200421 | 29 | CABG | 6 | 5 | No | 10 | 5 | No | Mortality, length of hospital stay, Pao2/Fio2 ratio, Paco2 level |
| Wrigge et al., 200422 | 32 | Thoracic surgery | 6 | 10 | No | 12 | 0 | No | Pao2/Fio2 ratio, Paco2 level |
| Wrigge et al., 200523 | 44 | Cardiac surgery | 6 | Adjusted by ARDSnet scale | No | 12 | Adjusted by ARDSnet scale | No | Length of ICU stay, Pao2/Fio2 ratio, Paco2 level |
| Zupancich et al., 200524 | 40 | CABG | 8 | 10 | No | 10–12 | 2–3 | No | Mortality, Pao2/Fio2 ratio, Paco2 level |
| Michelet et al., 200625 | 52 | Esophagectomy | 5 | 5 | No | 9 | 0 | No | Lung injury, pulmonary infection, mortality, Paco2 level |
| Cai et al., 200726 | 16 | Neurosurgery | 6 | NR | N:o | 10 | NR | No | Atelectasis, Pao2/Fio2 ratio, Paco2 level |
| Determann et al., 200827 | 40 | Abdominal surgery | 6 | 10 | No | 12 | 0 | No | Paco2 level |
| Lin et al., 200828 | 40 | Esophagectomy | 5–6 | 3–5 | No | 10 | 0 | No | Atelectasis |
| Weingarten et al., 201029 | 40 | Abdominal surgery | 6 | 12 | Yes | 10 | 0 | No | Lung injury, pulmonary infection, atelectasis, mortality, Pao2/Fio2 ratio, Paco2 level |
| Sundar et al., 201130 | 149 | Cardiac surgery | 6 | Adjusted by ARDSnet scale | No | 10 | Adjusted by ARDSnet scale | No | Mortality, Pao2/Fio2 ratio |
| Yang et al., 201131 | 100 | Lobectomy | 6 | 5 | No | 10 | 0 | No | Lung injury, pulmonary infection, atelectasis, mortality, length of hospital stay, length of ICU stay, Paco2 level |
| Memtsoudis et al., 201232 | 26 | Spinal surgery | 6 | 8 | No | 12 | 0 | No | Pao2/Fio2 ratio, Paco2 level |
| Treschan et al., 201233 | 101 | Abdominal surgery | 6 | 5 | Yes | 12 | 5 | Yes | Lung injury, pulmonary infection, mortality, length of hospital stay, length of ICU stay |
| Futier et al., 201334 | 400 | Abdominal surgery | 6–8 | 6–8 | Yes | 10–12 | 0 | No | Lung injury, pulmonary infection, atelectasis, mortality, length of hospital stay, length of ICU stay, Paco2 level |
| Maslow et al., 201335 | 32 | Thoracotomy | 5 | 5 | No | 10 | 0 | No | Lung injury, mortality, length of hospital stay, Pao2/Fio2 ratio, Paco2 level |
| Severgnini et al., 201336 | 55 | Abdominal surgery | 7 | 10 | Yes | 9 | 0 | No | Atelectasis, mortality |
| Shen et al., 201337 | 101 | Esophagectomy | 5 | 5 | No | 8 | 0 | No | Lung injury, pulmonary infection, mortality |
| Qutub et al., 201438 | 26 | Thoracoscopic surgery | 6 | 5 | No | 8 | 5 | No | Lung injury, pulmonary infection, atelectasis, mortality |
Note: ARDSnet = Acute Respiratory Distress Syndrome Network, CABG = coronary artery bypass graft surgery, Fio2 = fraction of inspired oxygen, ICU = intensive care unit, Paco2 = arterial partial pressure of carbon dioxide, Pao2 = arterial partial pressure of oxygen, PEEP = positive end-expiratory pressure.