Results of the meta-analysis of studies including the primary parameters of true-positive, false-positive, true-negative and false-negative
| Location, apnea–hypopnea cut-off | No. of studies | Overall heterogeneity | Sensitivity (95% CI) | Specificity (95% CI) | Area under the ROC curve (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| I2 (95% CI) | p value for Q statistic | |||||||
| Home, ≥ 5 events/h | 846,47,52,55,84,85,89,102 | 0 | 0.5 | 0.93 (0.90–0.95) | 0.60 (0.51–0.68) | 0.89 (0.86–0.92) | 2.3 (1.9–2.9) | 0.11 (0.07–0.16) |
| Laboratory, ≥ 5 events/h | 747,52,61,65,67,70,118 | 85 (68–100) | 0.001 | 0.96 (0.90–0.98) | 0.76 (0.63–0.85) | 0.92 (0.90–0.94) | 3.9 (2.6–6.1) | 0.05 (0.02–0.13) |
| Home, ≥ 10 events/h | 646,47,55,76,89,91 | 53 (0–100) | 0.06 | 0.83 (0.73–0.89) | 0.81 (0.70–0.89) | 0.89 (0.86–0.91) | 4.3 (2.7–7.0) | 0.22 (0.14–0.33) |
| Laboratory, ≥ 10 events/h | 647,48,58,61,65,70 | 0 | 0.3 | 0.92 (0.87–0.95) | 0.85 (0.77–0.90) | 0.93 (0.91–0.95) | 6.0 (4.0–8.9) | 0.09 (0.05–0.15) |
| Home, ≥ 15 events/h | 846–48,52,55,85,89,104 | 82 (62–100) | 0.002 | 0.79 (0.71–0.86) | 0.79 (0.63–0.89) | 0.85 (0.82–0.88) | 3.7 (2.1–6.7) | 0.26 (0.19–0.37) |
| Laborator, ≥15 events/h | 947,48,52,56,58,61,65,67,70 | 66 (23–100) | 0.03 | 0.92 (0.86–0.96) | 0.91 (0.85–0.95) | 0.97 (0.95–0.98) | 10.6 (6.1–18.2) | 0.08 (0.04–0.15) |
| Home, ≥ 30 events/h | 548,52,55,88,104 | 0 | 0.4 | 0.79 (0.72–0.85) | 0.90 (0.84–0.95) | 0.86 (0.83–0.89) | 8.2 (4.7–14.6) | 0.23 (0.16–0.32) |
| Laboratory, ≥ 30 events/h | 448,52,58,67 | 0 | 0.5 | 0.97 (0.92–0.99) | 0.93 (0.89–0.96) | 0.99 (0.98–1.00) | 14.9 (8.6–25.8) | 0.03 (0.01–0.08) |
Note: CI = confidence interval, LR = likelihood ratio, ROC = receiver operator characteristic.