Multivariable Cox proportional hazards regression analysis of the risk of end-stage renal disease among women with and without hypertensive disorders in pregnancy
| Variable, n of women | End-stage renal disease | Incidence rate per 10 000 person-years | Hazard ratio (95% confidence interval) | |||
|---|---|---|---|---|---|---|
| Model 1* | Model 2† | Model 3‡ | Model 4§ | |||
| No hypertensive disorders in pregnancy, n = 213 397 | 45 | 0.34 | 1.00 | 1.00 | 1.00 | 1.00 |
| Hypertensive disorders in pregnancy, n = 26 651 | 79 | 4.72 | 14.1 (9.76–10.3) | 12.4 (8.54–18.0) | 2.72 (1.76–4.22) | 1.91 (1.20–3.07) |
| Gestational hypertension, n = 8 653 | 18 | 3.40 | 10.2 (5.89–17.6) | 9.03 (5.20–15.7) | 1.81 (0.99–3.30) | 1.38 (0.74–2.57) |
| Preeclampsia/eclampsia, n = 17 998 | 61 | 5.33 | 15.9 (10.8–23.3) | 14. 0 (9.43–20.7) | 3.19 (2.02–5.02) | 2.17 (1.33–3.54) |
| p for trend | < 0.001¶ | < 0.001** | < 0.001** | < 0.001** | 0.001 | |
↵* Crude hazard ratio.
↵† Adjusted for urban status, coronary artery disease, congestive heart failure, hyperlipidemia and abruption.
↵‡ Adjusted for the variables in model 2, plus hypertension and diabetes during follow-up.
↵§ Time-depended model, adjusted for the variables in model 3.
↵¶ Poisson regression.
↵** Cox proportional hazards regression.