Table 1:

Results for serologic tests for HTLV, syphilis and hepatitis B in a 29-year-old man with acute biphenotypic leukemia who received intravenous immunoglobulin transfusion

TestResult
Before transfusionImmediately after transfusion5 wk after transfusion8 wk after transfusion
HTLV I/II
ELISANonreactive*Reactive†NTNonreactive
INNO-LIANTPositiveNTNegative
RIPANTIndeterminateNTNT
Syphilis
ELISANTReactiveNTNonreactive
Rapid plasma reaginNTNonreactiveNTNonreactive
Treponema pallidum particle agglutination assayNTNonreactiveNTNonreactive
INNO-LIANTNegativeNTNegative
Hepatitis B
Hepatitis B surface antigenNonreactiveNTNTNonreactive
Anti-HBsNTNTReactive (titre 719.6 IU/L)Reactive (titre 399.1 IU/L)‡
Anti-HBc (total)NTNTReactiveNonreactive§

  • Note: anti-HBc = antibody to hepatitis B core protein, anti-HBs = antibody to hepatitis B surface antigen, ELISA = enzyme-linked immunosorbent assay, HTLV = human T-lymphotropic virus, INNO-LIA = commercially available line immunoassay, NT = not tested, RIPA = radioimmunoprecipitation assay.

  • ↵* HTLV I/II ELISA was repeated on a serum sample obtained 2 wk before transfusion and was still nonreactive.

  • ↵† HTLV I/II ELISA was repeated on a serum sample obtained 4 d later and was still reactive.

  • ↵‡ Anti-HBs serology was repeated 4 mo later and was still reactive (titre 173.9 IU/L).

  • ↵§ Anti-HBc serology was repeated 4 wk later and was still nonreactive.