Association between atrial fibrillation (baseline and follow–up) and cognitive and functional outcomes among participants of the ONTARGET and TRANSCEND trials
| Outcome | All participants (no atrial fibrillation at baseline), no. % n = 29 916 | No atrial fibrillation, no. % n = 27 864 | Atrial fibrillation at baseline, no. % n =1 016 | New atrial fibrillation at follow-up, no. % n = 2 052 | All atrial fibrillation (baseline and follow-up), no. % n = 3 068 |
|---|---|---|---|---|---|
| Composite outcome* | n = 29 916 7 972 (26.7) | n = 27 864 7 269 (26.1) | n = 1 016 347 (34.1) | n = 2 052 703 (34.3) | n = 3 068 1 050 (34.2) |
| Decrease in MMSE score ≥ 3 | n = 27 003 4 524 (16.8) | n = 25 114 4 169 (16.6) | n = 843 171 (20.3) | n = 1 889 355 (18.8) | n = 2 732 526 (19.3) |
| Dementia during follow-up | n = 27 386 2 157 (7.9) | n = 25 521 1 972 (7.7) | n = 890 114 (12.8) | n = 1 865 185 (9.9) | n = 2 755 299 (10.9) |
| Loss of independence in ADL | n = 27 160 2 006 (7.4) | n = 25 272 1 775 (7.0) | n = 857 122 (14.2) | n = 1 888 231 (12.2) | n = 2 745 353 (12.9) |
| Admission to long-term care | n = 29 070 1 345 (4.6) | n = 27 052 1 183 (4.4) | n = 953 74 (7.8) | n = 2 018 162 (8.0) | n = 2 971 236 (7.9) |
Note: ADL = activities of daily living, MMSE = Mini–Mental State Examination.
↵* Decrease in MMSE score of 3 points or more, new diagnosis of dementia at follow-up, loss of independence with performing ADL and admission to a long-term care facilty.