Change in score on the headache inventory test at 3, 6 and 12 months for all participants and subgroups corrected for clustering, age, sex and score at baseline
| Subgroup/follow-up, mo | Intervention group | Control group | Adjusted between- group differences (95% CI) | p value | ||
|---|---|---|---|---|---|---|
| No. of respondents | Mean change (SE) | No. of respondents | Mean change (SE) | |||
| Total group | ||||||
| 3 | 181 | −2.64 (0.44) | 205 | −2.11 (0.39) | −0.72 (−1.80 to 0.36) | 0.19 |
| 6 | 181 | −3.12 (0.40) | 212 | −2.55 (0.36) | −0.81 (−1.68 to 0.06) | 0.07 |
| 12 | 181 | −4.01 (0.47) | 202 | −2.97 (0.41) | −1.23 (−2.45 to −0.00) | 0.05 |
| Patients not using prophylaxis at baseline | ||||||
| 3 | 115 | −2.83 (0.55) | 135 | −2.24 (0.46) | −1.22 (−2.15 to −0.29) | 0.01 |
| 6 | 118 | −3.51 (0.48) | 142 | −2.69 (0.44) | −1.18 (−2.14 to −0.21) | 0.02 |
| 12 | 120 | −4.14 (0.54) | 137 | −2.81 (0.48) | −1.59 (−2.85 to −0.32) | 0.01 |
| Patients with > 2 attacks/mo at baseline | ||||||
| 3 | 130 | −3.14 (0.51) | 139 | −2.13 (0.46) | −1.01 (−2.40 to 0.39) | 0.16 |
| 6 | 128 | −3.48 (0.45) | 140 | −2.35 (0.44) | −1.26 (−2.28 to −0.24) | 0.02 |
| 12 | 124 | −4.33 (0.56) | 137 | −2.37 (0.48) | −2.02 (−3.35 to −0.70) | 0.003 |
| Patients with no prophylaxis who had ≥ 2 attacks/mo at baseline | ||||||
| 3 | 82 | −3.05 (0.66) | 88 | −1.92 (0.51) | −1.31 (−2.83 to 0.20) | 0.09 |
| 6 | 82 | −3.82 (0.52) | 90 | −2.61 (0.54) | −1.37 (−2.64 to −0.20) | 0.04 |
| 12 | 81 | −4.15 (0.61) | 91 | −2.15 (0.57) | −2.16 (−3.72 to −0.60) | 0.007 |
Note: CI = confidence interval, SE = standard error.