Table 4:

Adjusted difference in average change in score for secondary outcomes between the intervention and control groups at follow-up at 3, 6 and 12 months corrected for clustering, age, sex and baseline score

Outcome at follow-up	Intervention group		Control group		Adjusted between- group differences (95% CI)	p value

	No. of respondents	Mean change (SE)	No. of respondents	Mean change (SE)
Migraine attacks, no./mo^*

3	173	−0.43 (0.16)	192	−0.41 (0.13)	−0.02 (−0.41 to 0.38)	0.94

6	171	−0.37 (0.17)	195	−0.48 (0.13)	0.07 (−0.33 to 0.46)	0.75

12	172	−0.83 (0.17)	193	−0.61 (0.15)	−0.29 (−0.63 to 0.04)	0.08

Headache, d/mo^†

3	170	−0.44 (0.26)	190	−0.37 (0.25)	−0.06 (−0.67 to 0.54)	0.84

6	168	−0.51 (0.30)	195	−0.59 (0.20)	0.20 (−0.37 to 0.77)	0.49

12	168	−1.08 (−0.26)	191	−0.32 (0.26)	−0.72 (−1.37 to −0.06)	0.03

Severity attacks, mean^†^‡

3	146	−0.07 (0.05)	164	−0.08 (0.04)	−0.04 (−0.14 to 0.06)	0.44

6	145	−0.71 (0.05)	163	−0.11 (0.04)	0.04 (−0.08 to 0.15)	0.53

12	136	−0.11 (0.05)	166	−0.03 (0.04)	−0.07 (−0.18 to 0.04)	0.22

Triptans used in previous month, no.

3	122	−0.44 (0.34)	151	−0.47 (0.30)	0.10 (−0.70 to 0.90)	0.81

6	117	−0.81 (0.37)	145	−0.40 (0.35)	−0.14 (−0.72 to 0.44)	0.64

12	116	−1.72 (0.44)	144	−0.83 (0.32)	−0.79 (−1.68 to 0.104)	0.08

Absence from work, d/mo

3	149	−0.08 (0.11)	165	−0.11 (0.13)	−0.02 (−0.28 to 0.23)	0.85

6	162	−0.01 (0.17)	185	−0.24 (0.09)	0.15 (−0.16 to 0.46)	0.33

12	142	0.04 (0.12)	166	−0.06 (0.11)	0.02 (−0.28 to 0.32)	0.88

Note: CI = confidence interval, SE = standard error.
↵* Attacks of maximum 72 h, attacks recurring within 24 h are considered to be a recurrence of the earlier attack.
↵† Days with at least four hours of headache.
↵‡ On a three-point scale (1 = mild, 2 = moderate, 3 = severe).