RT Journal Article
SR Electronic
T1 Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 43
OP 45
VO 131
IS 1
A1 Ring, F. A.
A1 Hershfield, N. B.
A1 Machin, G. A.
A1 Scott, R. B.
YR 1984
UL http://www.cmaj.ca/content/131/1/43.abstract
AB A diagnosis of idiopathic ulcerative colitis was made in a previously healthy 9-year-old boy. Symptoms persisted despite therapy with sulfasalazine, 50 mg/kg daily, but they eventually responded to treatment with parenteral nutrition and prednisone, 40 mg daily. Metronidazole was also given to eradicate persistent Dientamoeba fragilis from the stools. The symptoms resolved over 3 weeks, and the daily dose of prednisone was tapered. On two subsequent occasions a challenge with sulfasalazine caused an immediate recurrence of loose, blood-streaked stools and of nonspecific histologic features of ulcerative colitis, which resolved when the sulfasalazine was discontinued.