PT  - JOURNAL ARTICLE
AU  - Amy H. Cheung
AU  - Graham J. Emslie
AU  - Taryn L. Mayes
TI  - The use of antidepressants to treat depression in children and adolescents
AID  - 10.1503/cmaj.050855
DP  - 2006 Jan 17
TA  - Canadian Medical Association Journal
PG  - 193--200
VI  - 174
IP  - 2
4099  - http://www.cmaj.ca/content/174/2/193.short
4100  - http://www.cmaj.ca/content/174/2/193.full
SO  - CMAJ2006 Jan 17; 174
AB  - The dramatic increase over the past 10 years in the amount of available clinical research on the use of antidepressants to treat major depression in children and adolescents has substantially improved our knowledge of the safety and efficacy of these medications in the pediatric population. Many questions remain, however, that highlight the need to continue research in this patient population rather than relying on the extrapolation of data from trials involving adults. In this article, we review the current state of research into antidepressant therapy for major depression in children and adolescents. In addition, we discuss methodologic issues and clinical implications specific to the pediatric population.