PT  - JOURNAL ARTICLE
AU  - Singh, Jeffrey M.
AU  - Ball, Ian M.
AU  - Hartwick, Michael
AU  - Malus, Eli
AU  - Soliman, Karim
AU  - Boyd, John G.
AU  - Dhanani, Sonny
AU  - Healey, Andrew
TI  - Factors associated with consent for organ donation: a retrospective population-based study
AID  - 10.1503/cmaj.210836
DP  - 2021 Nov 15
TA  - Canadian Medical Association Journal
PG  - E1725--E1732
VI  - 193
IP  - 45
4099  - http://www.cmaj.ca/content/193/45/E1725.short
4100  - http://www.cmaj.ca/content/193/45/E1725.full
SO  - CMAJ2021 Nov 15; 193
AB  - Background: Optimizing the approach to and consent of potential organ donors maximizes patient autonomy and the availability of organs for transplants. We set out to identify modifiable factors associated with donation consent.Methods: We conducted a retrospective cohort study of consecutive adults (≥ 18 yr) referred for organ donation in Ontario between April 2013 and June 2019. We analyzed patient clinical data and demographics, data on substitute decision-makers and characteristics of the donation consent approach. Study outcomes were consent for organ donation and approach rate. We evaluated independent associations between consent and approach-and system-level factors.Results: We identified 34 837 referrals for organ donation, of which 6548 (18.8%) substitute decision-makers were approached for consent. Of these, 3927 (60.0% of approaches) consented for organ donation and 1883 (48.0% of consents) patients proceeded to be organ donors. The most common reason substitute decision-makers were not approached for consent in a case with donation potential was a late referral by the health care team (45.2%). Modifiable factors independently associated with consent included a telephone approach for consent (adjusted odds ratio [OR] 0.46, 95% confidence interval [CI] 0.35–0.58) and a collaborative approach by a physician and donation coordinator (adjusted OR 1.26, 95% CI 1.01–1.59).Interpretation: Consent for organ donation was associated with several modifiable factors. Organizations should target interventions to ensure timely referrals to organ donation organizations, increase in-person consent approaches and increase physician participation in the approach process.See related article at www.cmaj.ca/lookup/doi/10.1503/cmaj.190761