RT Journal Article SR Electronic T1 Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP E246 OP E248 DO 10.1503/cmaj.100467 VO 183 IS 4 A1 Navjeet Uppal A1 Baseer Yasseen A1 Winnie Seto A1 Christopher S. Parshuram YR 2011 UL http://www.cmaj.ca/content/183/4/E246.abstract AB Intravenous doses of medications require formulations that permit accurate preparation and administration. Current equipment does not permit accurate measurement of volumes less than 0.1 mL. In a study of four hypothetical standard pediatric patients, we found that 28 common medications required less than 0.1 mL of available formulation to prepare the dose. In a clinical study of actual use in a pediatric intensive care unit (ICU), 5245 (7.4%) of 71 218 intravenous doses required preparation from less than 0.1 mL of stock solution. For 28.5% of the 1531 ICU admissions, at least one dose was prepared from a volume of less than 0.1 mL. Our findings identify a substantial source of dosing error. Correction will require revision of preparation methods, regulatory requirements and manufacturing practices.