RT Journal Article SR Electronic T1 Influence of socioeconomic events on cause-specific mortality in urban Shanghai, China, from 1974 to 2015: a population-based longitudinal study JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP E1153 OP E1161 DO 10.1503/cmaj.180272 VO 190 IS 39 A1 Shuo Wang A1 Xiaoyu Du A1 Xue Han A1 Fan Yang A1 Jia Zhao A1 Hui Li A1 Mi Li A1 Hongwei Zhang A1 Wenbin Liu A1 Jiahui Song A1 Guangwen Cao YR 2018 UL http://www.cmaj.ca/content/190/39/E1153.abstract AB Background: Understanding how socioeconomic events influence cause-specific mortality is essential for optimizing disease-control strategies. We characterized long-term trends in cause-specific mortality in a stable population from a very large urban centre.Methods: We derived population data from 1974 to 2015 on vital status, demographics and causes of death from the death registration system in Yangpu District, Shanghai, China. We examined temporal trends in mortality and assessed the effects of age, period and birth cohort.Results: Over 41 879 864 person-years of follow-up, we analyzed 290 332 deaths: 3.80% from communicable conditions (group 1), 86.50% from noncommunicable diseases (group 2), and 5.56% from injuries (group 3). Age-standardized mortality decreased after 1988 for group 1 (average annual percentage change [AAPC] −6.7, 95% confidence interval [CI] −9.3 to −4.1), after 1995 for group 2 (AAPC −2.9, 95% CI −3.5 to −2.3), and after 1994 for group 3 (AAPC −5.4, 95% CI −6.3 to −4.5), after improvements in public health and clinical service infrastructure and the removal of polluting industries during the 1980s. We observed increased mortality from group 2 and group 3 causes in those born between 1955 and 1965, a period that included the Great Chinese Famine. Cause-specific mortality risks increased in those born after 1949 for cancer and diabetes only.Interpretation: Birth cohorts exposed to extreme starvation in early life had increased premature cause-specific mortality in later life. Decreased cause-specific mortality followed improvements in public health, medical infrastructure and pollution control, but not for cancer or diabetes, likely because of exposure to new risk factors.