@article {Wangcmaj.120230, author = {I-Kuan Wang and Chih-Hsin Muo and Yi-Chih Chang and JChih-Chia Liang and Chiz-Tzung Chang and Shih-Yi Lin and Tzung-Hai Yen and Feng-Rong Chuang and Pei-Chun Chen and Chiu-Ching Huang and Chi-Pang Wen and Fung-Chang Sung and Donald E. Morisky}, title = {Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study}, elocation-id = {cmaj.120230}, year = {2013}, doi = {10.1503/cmaj.120230}, publisher = {CMAJ}, abstract = {Background: Studies into the association between hypertensive disorders during pregnancy and end-stage renal disease are limited. We investigated the risk of end-stage renal disease after delivery among women with hypertensive disorders during pregnancy. Methods: We used insurance claims data from 1998 to 2009 to identify 26 651 women aged 19{\textendash}40 years old who experienced hypertensive disorders during pregnancy; these women had no history of hypertension, diabetes, kidney disease or lupus. We also randomly selected 213 397 women without hypertensive disorders during pregnancy as a comparison cohort; the frequency was matched by age and index year of pregnancy. We compared the incidence of end-stage renal disease in the 2 cohorts. We calculated hazard ratios (HRs) and 95\% confidence intervals (CIs) after controlling for demographic and clinical factors. Results: Women with hypertensive disorders during pregnancy had a greater risk of chronic kidney disease and end-stage renal disease, with adjusted HRs of 9.38 (95\% CI 7.09{\textendash}12.4) and 12.4 (95\% CI 8.54{\textendash}18.0), respectively, after controlling for urban status, coronary artery disease, congestive heart failure, hyperlipidemia and abruption. The HR for end-stage renal disease was 2.72 (95\% CI 1.76{\textendash}4.22) after we also controlled for hypertension and diabetes. Women with preeclampsia or eclampsia had a higher risk of end-stage renal disease (adjusted HR 14.0, 95\% CI 9.43{\textendash}20.7) than women who had gestational hypertension only (adjusted HR 9.03, 95\% CI 5.20{\textendash}15.7). Interpretation: Women with hypertensive disorders during pregnancy were at a high risk of end-stage renal disease. The risk was much greater for women who had preeclampsia or eclampsia than those who had gestational hypertension only.}, issn = {0820-3946}, URL = {https://www.cmaj.ca/content/early/2013/01/21/cmaj.120230}, eprint = {https://www.cmaj.ca/content/early/2013/01/21/cmaj.120230.full.pdf}, journal = {CMAJ} }