PT  - JOURNAL ARTICLE
AU  - Leon A. Adams
AU  - Paul Angulo
AU  - Keith D. Lindor
TI  - Nonalcoholic fatty liver disease
AID  - 10.1503/cmaj.045232
DP  - 2005 Mar 29
TA  - Canadian Medical Association Journal
PG  - 899--905
VI  - 172
IP  - 7
4099  - http://www.cmaj.ca/content/172/7/899.short
4100  - http://www.cmaj.ca/content/172/7/899.full
SO  - CMAJ2005 Mar 29; 172
AB  - NONALCOHOLIC FATTY LIVER DISEASE is emerging as the most common chronic liver condition in the Western world. It is associated with insulin resistance and frequently occurs with features of the metabolic syndrome. Disease presentation ranges from asymptomatic elevated liver enzyme levels to cirrhosis with complications of liver failure and hepatocellular carcinoma. Current treatment recommendations are limited to weight loss and exercise, although several promising medications are on the horizon. In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management.