RT Journal Article
SR Electronic
T1 Multiple myeloma in a patient with fever of unknown origin and cholestasis
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1809
OP 1810
DO 10.1503/cmaj.1031826
VO 170
IS 12
A1 Nicola Mumoli
A1 Marco Cei
A1 Roberto Incensati
A1 Serena Verzuri
YR 2004
UL http://www.cmaj.ca/content/170/12/1809.abstract
AB THE DIFFERENTIAL DIAGNOSIS OF FEVER of unknown origin includes infectious diseases, malignancies and connective tissue diseases. Multiple myeloma is not usually included in the differential diagnosis, nor is it considered a frequent cause of cholestasis in the absence of amyloidosis. We report a case of multiple myeloma in a patient presenting with a long-standing fever and cholestasis. The patient underwent a long and unfruitful series of diagnostic procedures, including liver biopsy. The clue to the diagnosis, established with a marrow biopsy, was the presence of a paraprotein in the serum.