RT Journal Article
SR Electronic
T1 The “hypertriglyceridemic waist” phenotype and glucose intolerance in pregnancy
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP E722
OP E725
DO 10.1503/cmaj.100378
VO 182
IS 15
A1 Diane Brisson
A1 Patrice Perron
A1 Simon-Pierre Guay
A1 Daniel Gaudet
A1 Luigi Bouchard
YR 2010
UL http://www.cmaj.ca/content/182/15/E722.abstract
AB Background: Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The “hypertriglyceridemic waist” phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy. Methods: Plasma triglycerides and waist girth were measured at 11–14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24–28 weeks of gestation. Results: A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02). Interpretation: Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance.