TY - JOUR T1 - The “hypertriglyceridemic waist” phenotype and glucose intolerance in pregnancy JF - Canadian Medical Association Journal JO - CMAJ SP - E722 LP - E725 DO - 10.1503/cmaj.100378 VL - 182 IS - 15 AU - Diane Brisson AU - Patrice Perron AU - Simon-Pierre Guay AU - Daniel Gaudet AU - Luigi Bouchard Y1 - 2010/10/19 UR - http://www.cmaj.ca/content/182/15/E722.abstract N2 - Background: Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The “hypertriglyceridemic waist” phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy. Methods: Plasma triglycerides and waist girth were measured at 11–14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24–28 weeks of gestation. Results: A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02). Interpretation: Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance. ER -