TY - JOUR T1 - Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke JF - Canadian Medical Association Journal JO - CMAJ SP - 1281 LP - 1284 VL - 162 IS - 9 AU - Michael D. Hill AU - Philip A. Barber AU - Jennifer Takahashi AU - Andrew M. Demchuk AU - Thomas E. Feasby AU - Alastair M. Buchan Y1 - 2000/05/02 UR - http://www.cmaj.ca/content/162/9/1281.abstract N2 - Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy. ER -