PT  - JOURNAL ARTICLE
AU  - Michael D. Hill
AU  - Philip A. Barber
AU  - Jennifer Takahashi
AU  - Andrew M. Demchuk
AU  - Thomas E. Feasby
AU  - Alastair M. Buchan
TI  - Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
DP  - 2000 May 02
TA  - Canadian Medical Association Journal
PG  - 1281--1284
VI  - 162
IP  - 9
4099  - http://www.cmaj.ca/content/162/9/1281.short
4100  - http://www.cmaj.ca/content/162/9/1281.full
SO  - CMAJ2000 May 02; 162
AB  - Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.