PT  - JOURNAL ARTICLE
AU  - Ferenczy, Alex
AU  - Coutlée, François
AU  - Franco, Eduardo
AU  - Hankins, Catherine
TI  - Human papillomavirus and HIV coinfection and the risk of neoplasias of the lower genital tract: a review of recent developments
DP  - 2003 Sep 02
TA  - Canadian Medical Association Journal
PG  - 431--434
VI  - 169
IP  - 5
4099  - http://www.cmaj.ca/content/169/5/431.short
4100  - http://www.cmaj.ca/content/169/5/431.full
SO  - CMAJ2003 Sep 02; 169
AB  - ONE OF THE RISK FACTORS FOR HUMAN PAPILLOMAVIRUS (HPV) INFECTION and subsequent lower genital tract neoplasias and cancers is impaired cell-mediated immunity. HIV-positive women with severe immunosuppression are 5 times more likely than HIV-negative women to have lower genital tract neoplasias. A corresponding increase in the risk of invasive vulvar and anal cancers, but not of cervical cancer, has also been observed among HIV-positive women. Treatment failure and recurrence of neoplasia occur much more frequently among HIV-positive than among HIV-negative women. In this review, we discuss recent advances in the understanding of the relation between HIV and HPV coinfection and the development of lower genital tract neoplasias and cancers in women. In addition, we present strategies for monitoring and treating noninvasive and invasive neoplasias of the lower genital tract in HIV-positive women.