TY - JOUR T1 - Helicobacter pylori: new developments and treatments JF - Canadian Medical Association Journal JO - CMAJ SP - 1565 LP - 1574 VL - 156 IS - 11 AU - SJO. Veldhuyzen van Zanten AU - P. M. Sherman AU - R. H. Hunt Y1 - 1997/06/01 UR - http://www.cmaj.ca/content/156/11/1565.abstract N2 - The authors highlight new developments in research on Helicobacter pylori. There is now consensus that all patients with newly diagnosed or recurrent duodenal or gastric ulcers who have a positive test result for H. pylori should be treated for the infection. Patients presenting with complications of ulcers, such as bleeding, should also be treated. H. pylori has recently been classified as a definite human carcinogen by the International Agency for Research on Cancer. In treatment, new combination regimens, consisting of 3 or 4 different drugs, cure the infection in more than 80% of patients. Currently, the best combinations are: (1) omeprazole (or another proton-pump inhibitor), clarithromycin and metronidazole, (2) omeprazole (or another proton-pump inhibitor), clarithromycin and amoxicillin, (3) bismuth subsalicylate, tetracycline and metronidazole, and (4) omeprazole, bismuth subsalicylate, tetracycline and metronidazole. ER -