TY - JOUR T1 - Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole JF - Canadian Medical Association Journal JO - CMAJ SP - 47 LP - 50 VL - 112 IS - 13 AU - W. T. Hughes AU - S. Feldman AU - S. K. Sanyal Y1 - 1975/06/14 UR - http://www.cmaj.ca/content/112/13/47.abstract N2 - Pneumocystis carinii pneumonitis (PCP) is fatal in 90 to 100% of the cases if no treatment is given. Trimethoprim-sulfamethoxazole (TMP-SMX) was used at one of two dosage levels in the treatment of 20 children with PCP and cancer. Of 14 patients treated with 20 mg TMP--100 mg SMX/kgd, 12 recovered and 2 died. Treatment of the fatal cases and one of the patients who recovered was supplemented with pentamidine. When six patients were treated with 4 to 7 mg TMP--20 to 35 mg SMX/kgd, four recovered and two died. Both fatal cases and one of the patients who recovered were also treated with pentamidine. There was no significant adverse effects from TMP-SMX. ER -