RT Journal Article
SR Electronic
T1 Cytogenetic findings in over 2000 amniocenteses
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 846
OP 850
VO 129
IS 8
A1 J. E. Allanson
A1 B. C. McGillivray
A1 J. G. Hall
A1 D. Shaw
A1 D. K. Kalousek
YR 1983
UL http://www.cmaj.ca/content/129/8/846.abstract
AB Between 1971 and 1981, 58 (2.8%) of 2037 amniocenteses performed in Vancouver revealed chromosome abnormalities, 25 of which were trisomy 21. Of the 58 referrals that yielded abnormalities, 37 (63.8%) were for a maternal age of 38 years or more. The rates of detection of such abnormalities for single-year intervals of maternal age beyond 35 years were comparable to those calculated from pooled data obtained in multicentre studies in the United States, Canada and Europe.