TY - JOUR T1 - Acute graft-versus-host disease after allogeneic bone marrow transplantation JF - Canadian Medical Association Journal JO - CMAJ SP - 969 LP - 974 VL - 129 IS - 9 AU - C. Perreault AU - M. Gyger AU - J. Boileau AU - Y. Bonny AU - S. Cousineau AU - M. Lacombe AU - R. Lavallee AU - E. Tawil AU - G. D'Angelo Y1 - 1983/11/01 UR - http://www.cmaj.ca/content/129/9/969.abstract N2 - In 25 patients receiving allogeneic bone marrow transplants methotrexate was used to prevent acute graft-versus-host disease (GVHD). Acute GVHD, grades 2 to 4, developed in only 5 (20%) of the patients. The incidence of acute GVHD in other series of recipients of bone marrow transplants has ranged from 5% to 76%. A review of the literature suggests that this variation cannot be completely accounted for by age, type of disease treated by transplantation or type of GVHD prophylaxis. However, transfusion of allogeneic lymphocytes that have not been completely inactivated by irradiation (e.g., in platelet and granulocyte preparations) and inadequate isolation-decontamination procedures may increase the probability of GVHD following bone marrow transplantation. ER -