Treatment of respiratory or ENT infection |
Burke et al. (7) | 114 | NA | 118 | 375 | 7 | 21 | Primary | Child | Acute otitis media | Yes | Yes | No | Yes | 3 |
Gottfarb et al. (8) | NA | 26 | 26 | 20/kg | 7 | 14 | Referral | Child | Persistent cough | No | ? | No | Yes | 1 |
Heikkinen et al. (9) | NA | 57 | 58 | 40/kg | 7 | 7 | Referral | Child | Prevention of acute otitis media | No | ? | No | No | 0 |
Hoberman et al. (10) | NA | 144 | 147 | 90/kg | 10 | 10 | Referral | Child | Acute otitis media | Yes | ? | Yes | Yes | 5 |
Jørgensen et al. (11) | 133 | NA | 137 | 1500 | 7 | 8 | Primary | Adult | Acute exacerbation of chronic bronchitis | No | No | No | Yes | 5 |
Kaiser et al. (12) | NA | 146 | 142 | 1125 | 5 | 7 | Primary | Adult | Common cold | Yes | Yes | No | Yes | 1 |
Leach et al. (13) | 52 | NA | 51 | 50/kg | 168 | NR | Primary | Child | Prevention of high-risk otitis media | No | ? | Yes | No | 0 |
Little et al. (14) | 1038 | NA | 1023 | 3000 | 7 | 28 | Primary | Adult | Acute lower respiratory tract infection | Yes | Yes | Yes | No | 5 |
Mandel et al. (15) | 83 | NA | 81 | 1000 | 14 | 28 | Referral | Child | Otitis media with effusion (glue ear) | No | No | No | Yes | 1 |
Mandel et al. (16) | 57 | NA | 54 | 40/kg | 14 | NR | Referral | Child | Prophylaxis for recurrent otitis media | No | ? | No | No | 0 |
Marchant et al. (17) | NA | 25 | 25 | 20/kg | 14 | 28 | Referral | Child | Chronic wet cough | Yes | No | Yes | Yes | 2 |
Meltzer et al. (18) | 251 | NA | 252 | 45/kg | 14 | 29 | Primary | Adult | Acute rhinosinusitis | No | ? | No | Yes | 7 |
Merenstein et al. (19) | 67 | NA | 68 | 1500 | 10 | 14 | Primary | Adult | Acute rhinosinusitis | No | ? | No | Yes | 10 |
Nduba et al. (20) | 330 | NA | 330 | 2000 | 7 | 14 | Primary | Adult | Acute bronchitis in a high-prevalence HIV-positive population | No | Yes | No | Yes | 5 |
Ruohola et al. (21) | NA | 39 | 40 | 45/kg | 7 | 7 | Primary | Child | Ear discharge from tympanostomy tube for glue ear | No | ? | No | No | 0 |
Rwalah et al. (22) | NA | 50 | 46 | 40/kg | 7 | NR | Referral | Child | Prevention of otitis media in otitis-prone children with new acute respiratory infection | No | ? | No | No | 0 |
Taylor et al. (23) | 56 | NA | 66 | 375 | 5 | 8 | Primary | Child | Presumed viral acute respiratory infection | Yes | Yes | No | Yes | 4 |
Wald et al. (24) | 41 | 44 | 48 | 40/kg | 10 | 10 | Primary or referral | Child | Acute rhinosinusitis | No | ? | No | Yes | 2 |
Williamson et al. (25) | 60 | NA | 63 | 1500 | 7 | 42 | Primary | Adult | Acute rhinosinusitis | No | ? | Yes | Yes | 0 |
Treatment of other infections |
Glupczynski et al. (26) | 22 | NA | 23 | 2000 | 8 | NR | Referral | Adult | Campylobacter gastritis | No | ? | No | No | 0 |
Huizinga et al. (27) | NA | 51 | 22 | 750 | 5 | 5 | Referral | Adult | Infected skin wounds (surgical and nonsurgical) | No | ? | No | Yes | 0 |
Nelson et al. (28) | 15 | NA | 15 | 100/kg | 5 | 6 | Primary | Child | Salmonella gastroenteritis | Yes | No | No | Yes | 5 |
Sclafani et al. (29) | NA | 86 | 81 | 40/kg | 30 | 30 | Referral | Child | Chronic adenotonsillar hypertrophy | No | ? | No | Yes | 2 |
Prevention or prophylaxis against infection |
Albu et al. (30) | NA | 50 | 50 | 1250 | 14 | NR | Referral | Adult | Postoperative prophylaxis (endoscopic sinus surgery) | No | ? | No | No | 0 |
Baecher et al. (31) | 16 | NA | 16 | 1000 | 5 | 7 | Referral | Adult | Prophylaxis for obstetric Streptococcus colonization | No | ? | No | Yes | 1 |
Balme et al. (32) | 39 | NA | 35 | Not stated | 5 | NR | Referral | Child | Prophylaxis for kerosene-associated pneumonitis | No | ? | Yes | No | 0 |
Brakenbury et al. (33) | NA | 88 | 97 | 375–750 | 5 | — ‡ | Referral | Child, adult | Prophylaxis for animal bites | No | ? | No | Yes | 2 |
Duff et al. (34) | 54 | NA | 54 | 1500 | 14 | 14 | Referral | Adult | Bacterial vaginosis in pregnancy | Yes | No | No | No | 1 |
Kumana et al. (35) | 38 | NA | 12 | 3000 | 1 | NR | Dental | Adult | Pharmacokinetics (antibiotic levels) in prophylaxis against endocarditis | No | ? | No | No | 0 |
Liang et al. (36) | 39 | NA | 34 | 750 | 28 | NR | Referral | Adult | Postoperative prophylaxis (endoscopic sinus surgery) | No | ? | No | No | 0 |
Shapiro et al. (37) | 205 | NA | 182 | 750 | 10 | 7 | Primary | Child, adult | Prophylaxis for Lyme disease after tick bite | No | ? | No | Yes | 1 |
Yip et al. (38) | NA | 65 | 65 | 375 | 1 | NR | Referral | Adult | Prevention of UTI after urodynamic study | No | ? | No | No | 0 |
Dental treatment or prophylaxis |
Arteagoitia et al. (39) | NA | 16 | 17 | 4000 | 5 | NR | Dental | Adult | Prophylaxis for dental extraction | No | ? | Yes | No | 0 |
Bulut et al. (40) | 15 | NA | 15 | 1500 | 5 | NR | Dental | Adult | Prophylaxis for dental extraction | No | ? | No | No | 0 |
Esposito et al. (41) | 165 | NA | 165 | 2000 | 1 | 7 | Dental | Adult | Prophylaxis for dental implant | No | ? | No | Yes | 3 |
Esposito et al. (42) | 254 | NA | 255 | 2000 | 1 | 7 | Dental | Adult | Prophylaxis for dental implant | No | ? | No | Yes | 0 |
Hafferjee et al. (43) | NA | 10 | 11 | 750 | 30 | NR | Dental | Adult | Periodontal infection | No | ? | No | No | 0 |
Lockhart et al. (44) | 96 | NA | 96 | 2000 | 1 | NR | Dental | Adult | Preoperative prophylaxis for tooth extraction or toothbrushing | No | ? | Yes | No | 0 |
Rooney et al. (45) | 16 | NA | 15 | 750 | 7 | 180 | Dental | Adult | Periodontal disease | No | ? | No | Yes | 0 |
Winkel et al. (46) | NA | 10 | 11 | 1500 | 10 | 24 | Dental | Adult | Periodontal disease | No | No | No | Yes | 1 |
Obstetric or gynecologic treatment or prophylaxis |
Almeida et al. (47) | 50 | NA | 56 | 2250 | 1 | NR | Referral | Adult | Prophylaxis for premature rupture of membranes | No | ? | No | No | 0 |
Peters et al. (48) | NA | 76 | 73 | 1500 | 7 or 14 | — ‡ | Referral | Adult | Prophylaxis for preterm delivery of twins | No | ? | No | No | 2 |
Other |
Chantelau et al. (49) | NA | 22 | 22 | 1500 | 3–20 | 20 | Referral | Adult | Foot ulcers in diabetic neuropathy | No | ? | No | Yes | 1 |
Khin et al. (50) | 22 | NA | 78 | 25/kg | 180 | NR | Primary | Child | Malabsorption and growth | No | ? | No | No | 0 |
Trehan et al. (51) | 952 | NA | 959 | 80–90/kg | 5 | 14 | Primary | Child | Severe acute malnutrition | No | Yes | Yes | Yes | 6 |
Total no. of studies | 28 | 18 | 45 | NA | NA | NA | 20 referral, 15 primary, 9 dental, 1 primary or referral | 26 adult, 17 child, 2 child and adult | 20 preventive or prophylaxis | 8 Yes | 6 Yes, 6 No, 33 uncertain | NA | 25 Yes, 20 No | NA |
Median or mean | | | | | | Median 14 | | | | | | | | Mean 2.7§ |
Total no. of participants | 4280 | 1005 | 5234 | | | | | | | | | | | |