Original Articles
Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis
Jicheng Lv, Parya Ehteshami, Mark J. Sarnak, Hocine Tighiouart, Min Jun, Toshiharu Ninomiya, Celine Foote, Anthony Rodgers, Zhang Hong, Haiyan Wang, Giovanni F.M. Strippoli and Vlado Perkovic
CMAJ June 24, 2013 cmaj.121468; DOI: https://doi.org/10.1503/cmaj.121468
Jicheng Lv
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Parya Ehteshami
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Mark J. Sarnak
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Hocine Tighiouart
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Min Jun
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Toshiharu Ninomiya
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Celine Foote
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Anthony Rodgers
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Zhang Hong
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Haiyan Wang
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Giovanni F.M. Strippoli
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Vlado Perkovic
The George Institute for Global Health (Lv, Ehteshami, Jun, Foote, Rodgers, Perkovic), The University of
Sydney, Sydney, Australia; Renal Division, Department of medicine (Lv, Zhang, Wang), Peking University First Hospital,
Beijing, China; Tufts Medical Center (Sarnak, Tighiouart), Boston, Mass.; the Department of Medicine and
Clinical Science Graduate School of Medical Sciences (Ninomiya), Kyushu University, Japan; the Centre for Kidney
Research (Strippoli), The Children's Hospital at Westmead, School of Public Health, The University of Sydney,
Sydney, Australia; the Department of Pharmacology and Epidemiology (Strippoli), Mario Negri Sud Consortium, S Maria
Imbaro, Chieti, Italy; and DIAVERUM Medical-Scientific Office (Strippoli), Lund, Sweden
Online Appendices
- Appendix 1 : Searching strategy
- Appendix 2 : Risk of bias
- Appendix 3 : Begg's funnel plot for the assessment of publication bias in studies examining the effect of intensive blood pressure lowering on kidney failure
- Appendix 4 : Subgroup analysis of intensive blood pressure lowering on kidney failure
- Appendix 5 : Intensive blood pressure lowering and cardiovascular outcomes in patients with chronic kidney disease