Presentation |
Macrocytic anemia, failure to thrive, lethargy, hypotonia, hyperreflexia, loss of milestones, microcephaly, irritability, glossitis (14), (15)
|
Diagnosis |
Megaloblastic anemia in infant Low serum B12 in infant and mother Maternal history of diet low in B12
|
Megaloblastic anemia in infant Low serum B12 in infant and mother Positive Schilling test in mother or history of maternal pernicious anemia
|
Treatment |
Cyanocobalamin (intramuscular or intravenous injection) daily, then tapered to weekly and monthly (17) Early introduction of B12-fortified foods (e.g., cereals or formula)
|
Prevention |
Maternal oral supplementation of B12 Oral supplementation of vitamin B12 Early introduction of B12-fortified foods (23)
|
|