Review
Alpha-1 antitrypsin deficiency: a commonly overlooked cause of lung disease
Sarah K. Brode, Simon C. Ling and Kenneth R. Chapman
CMAJ September 04, 2012 184 (12) 1365-1371; DOI: https://doi.org/10.1503/cmaj.111749
Sarah K. Brode
From the Department of Medicine (Brode, Chapman), Division of Respirology, University of Toronto; the Department of Paediatrics (Ling), University of Toronto; the Asthma and Airways Centre (Chapman), University Health Network; and the Division of Gastroenterology, Hepatology & Nutrition (Ling), The Hospital for Sick Children, Toronto, Ont.
MDSimon C. Ling
From the Department of Medicine (Brode, Chapman), Division of Respirology, University of Toronto; the Department of Paediatrics (Ling), University of Toronto; the Asthma and Airways Centre (Chapman), University Health Network; and the Division of Gastroenterology, Hepatology & Nutrition (Ling), The Hospital for Sick Children, Toronto, Ont.
MB ChBKenneth R. Chapman
From the Department of Medicine (Brode, Chapman), Division of Respirology, University of Toronto; the Department of Paediatrics (Ling), University of Toronto; the Asthma and Airways Centre (Chapman), University Health Network; and the Division of Gastroenterology, Hepatology & Nutrition (Ling), The Hospital for Sick Children, Toronto, Ont.
MD MSc
Submit a Response to This Article
Jump to comment:
No Responses have been published for this article.
In this issue
Article tools
Alpha-1 antitrypsin deficiency: a commonly overlooked cause of lung disease
Sarah K. Brode, Simon C. Ling, Kenneth R. Chapman
CMAJ Sep 2012, 184 (12) 1365-1371; DOI: 10.1503/cmaj.111749
Jump to section
- Article
- How does alpha-1 antitrypsin deficiency cause lung and liver disease?
- What is the usual presentation?
- Who should be screened?
- How is alpha-1 antitrypsin deficiency diagnosed?
- After diagnosis, which tests and monitoring should be performed?
- What options are available to treat lung disease?
- What is the role of augmentation therapy?
- Are there any treatment options for liver disease?
- Gaps in knowledge
- Acknowledgement
- Footnotes
- References
- Figures & Tables
- Related Content
- Responses
- Metrics
Related Articles
Cited By...
- Opportunities to improve asthma and COPD prevention and care: insights from the patient journey obtained through focus groups
- FOOTPRINTS study protocol: rationale and methodology of a 3-year longitudinal observational study to phenotype patients with COPD
- Difficultes liees au diagnostic de deficit en {alpha}1-antitrypsine en soins de premiere ligne
- Challenge of {alpha}1-antitrypsin deficiency diagnosis in primary care
- Genetic susceptibility in the workplace: a scientific and ethical challenge