We thank Giuseppe Lippi and colleagues for their comments. The average serum level of IMA that they reported in their study (94 μ/mL, 97.5% confidence interval 84-104 μ/mL) is higher than the 2 cutoffs we employed: 85 μ/mL (suggested by the manufacturer) and 80 μ/mL. In our paper we indicated that we explored multiple IMA thresholds (including 100 μ/mL) but this did not alter our findings.1 Therefore, in patients presenting with chest pain who have not yet experienced a serious cardiac outcome, IMA appears to be a poor predictor of serious cardiac outcomes.
REFERENCE
- 1.↵