CMAJ • October 13, 2009; 181 (8). First published September 28, 2009; doi:10.1503/cmaj.081729
© 2009 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Incidence and causes of heparin-induced skin lesions

Marc Schindewolf, MD, Svantje Schwaner, MD, Manfred Wolter, MD, Hartmut Kroll, MD, Andreas Recke, MD, Roland Kaufmann, MD, Wolf-Henning Boehncke, MD, Edelgard Lindhoff-Last, MD and Ralf J. Ludwig, MD

From the Departments of Internal Medicine, Division of Angiology (Schindewolf, Lindhoff-Last), and Dermatology (Schwaner, Wolter, Kaufmann, Boehncke, Ludwig), Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany, the DRK-Blooddonorservice (Kroll), Dessau, Germany, and the Department of Dermatology (Recke), University of Lübeck, Lübeck, Germany


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  		Table 1: Characteristics of the study cohort

 

Figure 18
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  		Figure 1: Clinical spectrum of heparin-induced cutaneous delayed-type hypersensitivity responses. A: A red macula with few papules at a heparin-injection site. B: Widespread erythema and red papules originating from heparin-injection sites on the abdomen. C: Generalized red plaques on the entire abdomen. D: Generalized red papules on the entire abdomen originating from heparin injection sites.

 

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  		Table 2: Risk factors for heparin-induced skin lesions*