CMAJ • September 1, 2009; 181 (5). First published August 4, 2009; doi:10.1503/cmaj.081720
© 2009 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study

George Ioannidis, PhD, Alexandra Papaioannou, MD, Wilma M. Hopman, MSc, Noori Akhtar-Danesh, PhD, Tassos Anastassiades, MD, Laura Pickard, MA, Courtney C. Kennedy, MSc, Jerilynn C. Prior, MD, Wojciech P. Olszynski, MD PhD, Kenneth S. Davison, PhD, David Goltzman, MD, Lehana Thabane, PhD, Amiran Gafni, PhD, Emmanuel A. Papadimitropoulos, PhD, Jacques P. Brown, MD, Robert G. Josse, MD, David A. Hanley, MD and Jonathan D. Adachi, MD

From the Departments of Medicine (Ioannidis, Papaioannou, Pickard, Kennedy, Adachi), Nursing (Akhtar-Danesh) and Clinical Epidemiology and Biostatistics (Thabane, Gafni), McMaster University, Hamilton, Ont.; the Departments of Community Health and Epidemiology (Hopman) and Medicine (Anastassiades), Queen’s University, Kingston, Ont.; the Department of Medicine (Prior), University of British Columbia, Vancouver, BC; the Department of Medicine (Olszynski), University of Saskatchewan, Saskatoon, Sask.; the Department of Medicine (Brown, Davison), Laval University, Sainte-Foy, Que.; the Department of Medicine (Goltzman), McGill University, Montréal, Que.; Outcomes Research (Papadimitropoulos), Eli Lilly and Company, Toronto, Ont.; the Department of Medicine (Josse), University of Toronto, Toronto, Ont., and the Department of Medicine (Hanley), University of Calgary, Calgary, Alta.


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  		Table 1: Baseline characteristics of 7753 participants enrolled in an observational study of the relation between fractures and mortality

 

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  		Table 2: Incidence of fractures during the 5-year follow-up period, by type of fracture

 

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  		Table 3: Risk of death by type of fracture

 

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  		Table 4: Absolute rates of death by fracture type

 

Figure 19
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  		Figure 1: Adjusted* hazard ratios of death among participants with incident hip fracture and death. Adjustments were made for the variables listed in Table 1. Note: CI = confidence interval.

 

Figure 29
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  		Figure 2: Adjusted hazard ratios of death among participants with incident vertebral fracture and death. Adjustments were made for the variables listed in Table 1. Note: CI = confidence interval.