CMAJ • June 9, 2009; 180 (12). doi:10.1503/cmaj.081777.
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Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis

Prakesh S. Shah, MD MSc, Arne Ohlsson, MD MSc on behalf of the Knowledge Synthesis Group on Determinants of Low Birth Weight and Preterm Births

From the Department of Paediatrics (Shah, Ohlsson), Mount Sinai Hospital and University of Toronto, and the Departments of Health Policy, Management and Evaluation (Shah, Ohlsson), and Obstetrics and Gynaecology (Ohlsson), University of Toronto, Toronto, Ont.


Figure 132
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Figure 1: Selection of studies for meta-analysis of the effect of prenatal supplementation with multimicronutrients on pregnancy outcomes.

 

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Table 1: Brief description of the studies included in the meta-analysis of multimicronutrient supplementation during pregnancy

 

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Table 2: Composition of micronutrients in studies included in the meta-analysis

 

Figure 232
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Figure 2: Random-effect meta-analysis of the risk of low-birth-weight infants among women given multimicronutrient supplementation versus control (placebo or iron–folic acid supplementation) during pregnancy. Values less than 1.0 indicate decreased risk of outcome with multimicronutrient supplementation. Note: CI = confidence interval.

 

Figure 332
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Figure 3: Random-effect meta-analysis of the risk of preterm birth among women given multimicronutrient supplementation versus control (placebo or iron–folic acid supplementation) during pregnancy. Values less than 1.0 indicate decreased risk of outcome with multimicronutrient supplementation. Note: CI = confidence interval.

 

Figure 432
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Figure 4: Random-effect meta-analysis of the risk of small-for-gestational-age infants among women given multimicronutrient supplementation versus control (placebo or iron–folic acid supplementation) during pregnancy. Values less than 1.0 indicate decreased risk of outcome with multimicronutrient supplementation. Note: CI = confidence interval.

 

Figure 532
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Figure 5: Random-effect meta-analysis of the effect on birth weight of multimicronutrient supplementation versus control (placebo or iron–folic acid supplementation) during pregnancy. Values greater than zero indicate increased birth weight with multimicronutrient supplementation. Note: CI = confidence interval.

 

Figure 632
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Figure 6: Random-effect meta-analysis of the effect on gestational age of prenatal multimicronutrient supplementation versus control (placebo or iron–folic acid supplementation) during pregnancy. Values less than zero indicate increased gestational age with multimicronutrient supplementation. Note: CI = confidence interval.