CMAJ • December 2, 2008; 179 (12). doi:10.1503/cmaj.080859.
© 2008 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes

Shi Wu Wen, MB PhD, Jia Zhou, MB MSc, Qiuying Yang, MD PhD, William Fraser, MD MSc, Olufemi Olatunbosun, MD and Mark Walker, MSc MD

From the OMNI (Obstetrics, Maternal, and Neonatal Investigation) Research Group (Wen, Zhou, Yang, Walker), Department of Obstetrics and Gynecology, and the Department of Epidemiology and Community Medicine (Wen, Walker), Faculty of Medicine, University of Ottawa, Ottawa, Ont.; the Clinical Epidemiology Program (Wen, Zhou, Yang, Walker), Ottawa Health Research Institute, Ottawa, Ont.; the School of Public Health (Zhou), Central South University, Changsha, Hunan, China; the Department of Obstetrics and Gynecology (Fraser), Faculty of Medicine, Université de Montréal, Montréal, Que.; and the Department of Obstetrics and Gynecology (Olatunbosun), Faculty of Medicine, University of Saskatchewan, Saskatoon, Sask.


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Figure 115
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  		Figure 1: Comparison of adverse pregnancy outcomes between women exposed to folic-acid antagonists during pregnancy and women not exposed to these agents. *Adjusted for year of birth, type of institution at birth, maternal age, parity, social assistance and sex of the infant.