CMAJ • May 6, 2008; 178 (10). doi:10.1503/cmaj.071068.
© 2008 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Selective serotonin reuptake inhibitors for unipolar depression: a systematic review of classic long-term randomized controlled trials

Dorian Deshauer, MD MSc, David Moher, PhD, Dean Fergusson, PhD, Ester Moher, BA, Margaret Sampson, MLIS and Jeremy Grimshaw, MD PhD

From the Department of Psychiatry (Deshauer) and the Department of Epidemiology and Community Medicine (D. Moher, Fergusson, Grimshaw), University of Ottawa, Ottawa, Ont.; the Department of Psychology (E. Moher), University of Waterloo, Waterloo, Ont.; and the Chalmers Research Group (D. Moher, Sampson), Ottawa, Ont.


Figure 117
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  		Figure 1: Two designs of randomized controlled trials used to investigate long-term antidepressant therapy.

 

Figure 217
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  		Figure 2: Flow diagram for identification of classic placebo-controlled randomized controlled trials.

 

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  		Table 1.

 

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  		Table 2.

 

Figure 317
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  		Figure 3: Pooled analysis of response to treatment (50% improvement in depression score relative to baseline) in 6 classic randomized controlled trials of selective serotonin reuptake inhibitors in patients with major depression. The vertical line represents no difference between compared treatments.

 

Figure 417
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  		Figure 4: Pooled analysis of remission (score of 7 or below on the Hamilton rating scale for depression) in 4 classic randomized controlled trials of selective serotonin reuptake inhibitors in patients with major depression. The vertical line represents no difference between compared treatments.

 

Figure 517
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  		Figure 5: Pooled analysis of overall acceptability (total dropouts) in 6 classic randomized controlled trials of selective serotonin reuptake inhibitors in patients with major depression. The vertical line represents no difference between compared treatments.

 

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  		Table 3.