CMAJ • March 28, 2006; 174 (7). First published March 3, 2006; doi:10.1503/cmaj.051322
© 2006 CMA Media Inc. or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial

Woei-Cherng Shyu, Shinn-Zong Lin, Chau-Chin Lee, Demeral David Liu and Hung Li

From the Neuro-Medical Scientific Center, Buddhist Tzu-Chi General Hospital (Shyu, Lin, Lee, Liu), Tzu-Chi University, Hualien, and the Institute of Molecular Biology, Academia Sinica (Li), Taipei, Taiwan


Figure 116
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  		Fig. 1: Flow of participants through the study.

 

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  		Table 1.

 

Figure 216
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  		Fig. 2: Diffusion-weighted MRI scans at baseline of patients in the G-CSF (n = 7) and control (n = 3) groups.

 

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  		Table 2.

 

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  		Table 3.

 

Figure 316
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  		Fig. 3: Percent change in mean stroke scale scores between baseline and 12-month follow-up: (A) NIHSS, (B) EMS, (C) ESS, (D) BI. *p < 0.05.

 

Figure 416
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  		Fig. 4: Changes in EMS score in the G-CSF and control groups between baseline and 12 months. *p < 0.05.

 

Figure 516
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  		Fig. 5: Fusion images of MRI and PET at 12-month follow-up; (A) are of a G-CSF patient and (B) of a control patient. The images show successive views from the base of the skull (top left) to the vertex (bottom right). Areas of increasing metabolic activity, indicated by yellow and red colour, are distributed around the infarcted core, which is indicated by deep blue. Differences between the ipsilateral and contralateral hemispheres of the brain have been corrected.

 

Figure 616
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  		Fig. 6: Correlation between PET-generated data and clinical neurologic analysis. The relation between the ratio of fluorodeoxyglucose radioactivity in regions surrounding the infarction core and mean European Stroke Scale Motor Subscale (EMS) score was significant in the G-CSF group (r = 0.78; p = 0.01).