CMAJ • April 22, 2008; 178 (9). doi:10.1503/cmaj.080282.
© 2008 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Mechanisms and innovations

Traumatic brain injury: Can the consequences be stopped?

Eugene Park, PhD, Joshua D. Bell, BSc and Andrew J. Baker, MD

From the Cara Phelan Centre for Trauma Research (Park, Bell, Baker), Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital; and the Institute of Medical Science, Departments of Anesthesia and Surgery (Bell, Baker), University of Toronto, Toronto, Ont.

Correspondence to: Dr. Andrew J. Baker, St. Michael's Hospital, Bond Wing 7-086, 30 Bond St., Toronto, ON M5B 1W8; fax 416 864-5512; bakera{at}smh.toronto.on.ca

Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention.


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Can. Med. Assoc. J. 2008 178: 1109. [Full Text] [PDF]

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