CMAJ • January 30, 2007; 176 (3). doi:10.1503/cmaj.060360.
© 2007 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Research

Case report

Severe necrotizing pancreatitis following combined hepatitis A and B vaccination

Eran Shlomovitz, Ward Davies, Ewa Cairns, William C. Brintnell, Mark Goldszmidt and George K. Dresser

From the General Surgery Residency Program (Shlomovitz), Department of Surgery, University of Toronto, Toronto; the Divisions of General Surgery (Davies), General Internal Medicine (Dresser, Goldszmidt), Clinical Pharmacology (Dresser) and Rheumatology (Cairns, Brintnell), and the Departments of Surgery (Davies), Immunology and Microbiology (Cairns, Brintnell) and Medicine (Dresser, Goldszmidt), London Health Sciences Centre, University of Western Ontario, London, Ont.

Correspondence to: Dr. Eran Shlomovitz, General Surgery Residency Program, Department of Surgery, University of Toronto, Rm 440, Mount Sinai Hospital, 600 University Ave, Toronto ON M5G 1X5; eran.shlomo{at}gmail.com.

Necrotizing pancreatitis is a severe form of pancreatitis and is associated with substantial morbidity and mortality. We report a case of necrotizing pancreatitis that developed following combined hepatitis A and B vaccination. No other causes of pancreatitis could be determined. Although confirming the diagnosis is challenging, 3 main factors suggest a possible link to the vaccine: the chronology of the events, the patient's human leukocyte antigen genotype and the incongruent immune response to the vaccine components. This report serves to alert physicians to the possible development of necrotizing pancreatitis after vaccination.


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Can. Med. Assoc. J. 2007 176: 301. [Full Text] [PDF]

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Can. Med. Assoc. J. 2007 176: 301. [Full Text] [PDF]



eLetters:

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Vaccination Age
Jayendra R Gohil
CMAJ, 7 Jan 2009 [Full text]
Re: Vaccination Age
Eran Shlomovitz
CMAJ, 12 Jan 2009 [Full text]