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Natriuretic peptides in the diagnosis and management of heart failure

From the Outcomes Research Group, Duke Clinical Research Institute, and the Division of Cardiology and Department of Medicine, Duke University Medical Center, Durham, NC (all authors).

Correspondence to: Dr. Daniel B. Mark, Outcomes Group, Duke Clinical Research Institute, PO Box 17969, Durham NC 27705, USA; fax 919 668-7060; mark0004{at}mc.duke.edu

Abstract

The natriuretic peptides are a family of related hormones that play a crucial role in cardiovascular homeostasis. They have recently emerged as potentially important clinical markers in heart failure. Recent data have suggested an important role for these markers in establishing the diagnosis of heart failure in patients with unexplained dyspnea in both acute care and ambulatory settings. Other clinical uses of the natriuretic peptides, such as screening for asymptomatic ventricular dysfunction, establishing prognosis or guiding titration of drug therapy, are under investigation but have not yet sufficiently been validated for widespread clinical use.

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