CMAJ • August 29, 2006; 175 (5). doi:10.1503/cmaj.060218.
© 2006 CMA Media Inc. or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Review

Sperm DNA damage: clinical significance in the era of assisted reproduction

Armand Zini and Jamie Libman

From the Division of Urology, Department of Surgery, McGill University, Montréal, Que.

Correspondence to: Dr. Armand Zini, Rm. 2304, St. Mary's Hospital, 3830 Lacombe Ave., Montréal QC H3T 1M5; fax 514 734-2718; armand.zini{at}ssss.gouv.qc.ca

Abstract

Evidence suggests that damage to human sperm DNA might adversely affect reproductive outcomes and that the spermatozoa of infertile men possess substantially more sperm DNA damage than do the spermatozoa of fertile men. This is particularly relevant in an era where advanced forms of assisted reproductive technologies are commonly used (technologies that often bypass the barriers to natural selection), because there is some uncertainty regarding the safety of using DNA-damaged spermatozoa. In this review, we outline our current understanding of how sperm DNA is organized, what causes sperm DNA damage, what impact this damage may have on reproductive capacity and whether tests of sperm DNA damage are clinically useful.




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