CMAJ • December 5, 2006; 175 (12). doi:10.1503/cmaj.060542.
© 2006 CMA Media Inc. or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Review

Recognition and management of neuropsychiatric complications in Parkinson's disease

Florian Ferreri, Catherine Agbokou and Serge Gauthier

From the Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, Douglas Hospital, Verdun, Que. (Ferreri, Agbokou, Gauthier), and the Department of Psychiatry, Montreal Neurological Institute and Hospital, McGill University Health Centre, Montréal, Que. (Ferreri, Agbokou)

Correspondence to: Dr. Serge Gauthier, McGill Centre for Studies in Aging, 6825 Blvd. LaSalle, Verdun QC H4H 1R3; serge.gauthier{at}mcgill.ca

Abstract

Parkinson's disease is primarily considered a motor disease characterized by rest tremor, rigidity, bradykinesia and postural disturbances. However, neuropsychiatric complications, including mood and anxiety disorders, fatigue, apathy, psychosis, cognitive impairment, dementia, sleep disorders and addictions, frequently complicate the course of the illness. The pathophysiologic features of these complications are multifaceted and include neuropathophysiologic changes of a degenerative disease, exposure to antiparkinsonian treatments and emotional reactions to having a disabling chronic illness. Changes in mental status have profound implications for the well-being of patients with Parkinson's disease and of their caregivers. Treatment is often efficacious but becomes a challenge in advanced stages of Parkinson's disease. In this article, we review the key clinical features of neuropsychiatric complications in Parkinson's disease as well as what is known about their epidemiologic characteristics, risk factors, pathophysiologic features and management.


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Can. Med. Assoc. J. 2006 175: 1501. [Full Text] [PDF]

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Can. Med. Assoc. J. 2006 175: 1501. [Full Text] [PDF]



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