CMAJ • June 20, 2006; 174 (13). doi:10.1503/cmaj.051446.
© 2006 CMA Media Inc. or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Research

Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus

Carlo Bellini, Francesco Campone and Giovanni Serra

All of the authors are from the Neonatal Intensive Care Unit, Department of Pediatrics, University of Genoa, Gaslini Institute, Genoa, Italy.

Correspondence to: Dr. Carlo Bellini, Dipartimento di Pediatria, Università di Genova, Instituto G. Gaslini, Largo G. Gaslini, 5, 16147 Genova, Italy; fax +39 10 3770675; carlobellini{at}ospedale-gaslini.ge.it

Patent ductus arteriosus is one of the most common congenital abnormalities found in premature infants. Ibuprofen, a nonsteroidal drug that is commonly used as an antipyretic, analgesic and anti-inflammatory agent, is also used to induce closure of symptomatic patent ductus arteriosus in preterm infants. Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension. Only 3 cases of pulmonary hypertension following early administration of an ibuprofen solution buffered with tromethamine have previously been reported. However, this severe side effect has never been observed in multicentre, randomized, double-blind controlled trials, nor in recent reviews or meta-analyses of L-lysine ibuprofen use.


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