CMAJ • July 5, 2005; 173 (1). doi:10.1503/cmaj.050105.
© 2005 CMA Media Inc. or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Review
Synthèse

Bordetella pertussis: the intersection of genomics and pathobiology

Andrew Preston

Andrew Preston is with the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ont.

Correspondence to: Dr. Andrew Preston, Department of Molecular and Cellular Biology, University of Guelph, 172–50 Stone Rd. E, Guelph ON N1G 2W1; fax 519 837-1802; apreston{at}uoguelph.ca

Abstract

THERE HAS BEEN MUCH RECENT CONCERN over an increasing incidence of pertussis despite high levels of vaccine coverage of infants. Many reports have documented that much of the increased incidence is due to infection in adolescents and adults. This renewal of interest in pertussis comes at a time when the findings of the Bordetella genome project have led to a quantum leap forward in our understanding of the biology, evolution and pathogenesis of the bacterium responsible for the disease. The impact of this basic research on current clinical problems posed by B. pertussis infection is discussed.


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Can. Med. Assoc. J. 2005 173: 9. [Full Text] [PDF]