CMAJ • September 14, 2004; 171 (6). doi:10.1503/cmaj.1040631.
© 2004 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Case Report

Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray

Andrea H.S. Loewen, Mark E. Hudon and Michael D. Hill

From the Departments of Medicine (Loewen, Hill), Radiology (Hudon), Clinical Neurosciences (Hudon, Hill) and Community Health Sciences (Hill), Faculty of Medicine, University of Calgary, Calgary, Alta.

OXYMETAZOLINE IS A SYMPATHOMIMETIC amine found in over-the-counter nasal decongestants. We report a case of chronic use of nasal oxymetazoline associated with thunderclap headache due to reversible segmental intracranial vasoconstriction.




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A. Ducros, M. Boukobza, R. Porcher, M. Sarov, D. Valade, and M.-G. Bousser
The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients
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[Abstract] [Full Text] [PDF]